A study on the clinical, biochemical and hormonal profile of polycystic ovary syndrome patients attending tertiary care hospital

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder of reproductive age affecting 5% to 10% of women worldwide. It is a heterogenous, multifactorial, complex genetic disorder. PCOS receives a considerable attention because of its high prevalence and metabolic, reproductive and cardiovascular consequences.Methods: A cross sectional observation study of 100 PCOS patients was carried out between January 2014 to July 2015 in Gynaecology out-patient and Infertility OPD, Justice K. S. Hegde charitable hospital, Mangalore. The clinical, biochemical and hormonal profile of these patients were analysed and correlation was done between clinical features and biochemical and hormonal profile.Results: The prevalence of PCOS was 6.3% in the Gynaecology out-patient visits and 37.14% among infertile women. Menstrual irregularity was the most common complaint accounting for 31% followed by infertility (23%). Elevated leutinizing hormone and elevated LH: FSH was significant in irregular menstrual group. The prevalence of metabolic syndrome in our study was 21.3%. Spearmans correlation between various clinical and laboratory parameters showed menstrual cycle and body mass index(BMI) had a fair positive correlation and was significant. WHR (waist hip ratio) showed 21 times risk for metabolic syndrome.Conclusions: The study showed that most of our polycystic ovary syndrome subjects were hirsute, with central obesity and overweight or obese. Oligomenorrhea was the most common presentation. Among the various risk factors studied, WHR (waist hip ratio) showed 21 times risk for metabolic syndrome. Obese women with PCOS had more severe ovulatory dysfunction and need more attention for their appropriate management

A Movement of Mobile Sink in Wireless Sensor Network to Conserve Energy

Energy is the major constraint in wireless sensor network. In wireless sensor network with static mobile collector (SNSMC),static nodes located near to sink consume more energy, since the nodes relay the data collected by sensor nodes far away from the sink. The battery drained in short time. This problem is resolved by the MMC-WSN method. While simplifying the routing process, proposing an energy-efficient routing technique based on cluster based method for mobile sink is preferred. First part ,the selection of cluster head (CH) in cluster based method made periodically according to their residual energy and in second part the mobile sink moves across the sensing field and directly collects data from cluster heads and returns to back to initial site in a specific sequence based on spanning graphs. The spanning graph includes the shortest search path for the MS. Finally, a tour-planning algorithm is used on the basis of the spanning graph. An energy efficient routing technique (EFR) in WSNs among obstacles uses the shortest route. In this way, the mobile sink retrieves all detected knowledge among a given time and sends to base station which reduces the packet delay and energy-consumption and WSNs

Retrieving Data from Encrypted file by using Cosine Similarity

Nowadays every user who uses Internet wants to search for anything and everything using Search Engines. This is the need for everyone. To engineer a search engine is a challenging task. Search engines index tens to hundreds of millions of files involving a comparable number of distinct terms. They answer tens of millions of queries every day. Due to rapid advance in technology and need for information security, creating a web search engine today is very different from three years ago. The overall goal of this project is to develop a scalable, high performance search engine which searches the encrypted data without decryption. The main focus is on the algorithmic challenges and encryption while supporting fast searches on it. To develop this project, an applied ranking algorithm to give better results to the user and also used other algorithms to encrypt the data stored. To ease for searching of various information over the data by giving search keywords requires software. The search engine software ensures the end user to get the information by accessing the data specified in the database

Bengal

www.biogeosciences.net/11/3819/2014

A novel approach to jointly address localization and classification of breast cancer using bio-inspired approach

Localization of the cancerous region as well as classification of the type of the cancer is highly inter-linked with each other. However, investigation towards existing approaches depicts that these problems are always iindividually solved where there is still a big research gap for a generalized solution towards addressing both the problems. Therefore, the proposed manuscript presents a simple, novel, and less-iterative computational model that jointly address the localization-classification problems taking the case study of early diagnosis of breast cancer. The proposed study harnesses the potential of simple bio-inspired optimization technique in order to obtained better local and global best outcome to confirm the accuracy of the outcome. The study outcome of the proposed system exhibits that proposed system offers higher accuracy and lower response time in contrast with other existing classifiers that are freqently witnessed in existing approaches of classification in medical image process

Advancement in Research Techniques on Medical Imaging Processing for Breast Cancer Detection

With the advancement of medical image processing, the area of the healthcare sector has started receiving the benefits of the modern arena of diagnostic tools to identify the diseases effectively. Cancer is one of the dreaded diseases, where success factor of treatment offered by medical sector is still an unsolved problem. Hence, the success factor of the treatment lies in early stage of the disease or timely detection of the disease. This paper discusses about the advancement being made in the medical image processing towards an effective diagnosis of the breast cancer from the mammogram image in radiology. There has been enough research activity with various sorts of advances techniques being implemented in the past decade. The prime contribution of this manuscript is to showcase the advancement of the technology along with illustration of the effectiveness of the existing literatures with respect to research gap

Minimally invasive plate osteosynthesis of lower end of femur fractures using locking compression plating: a prospective study

Background: The treatment of distal femur fractures has recently evolved towards indirect reduction and minimally invasive techniques. The goal is to strike a balance between the mechanical stability of the fragments and the biological viability. Pre-contoured Locking compression plates (LCPs) have shown to give best results in terms of recovery, fracture union, return to work and functional outcome. Advent of MIPO technique has reduced the amount of soft tissue injury, delayed healing, tissue necrosis and infections.The objective was to study the functional result of fracture distal femur treated by closed reduction with LCP by minimally invasive plate osteosynthesis (MIPO).Methods: 20 cases of fracture distal end of femur were treated by closed reduction and internal fixation using LCP by MIPO between 1st October 2013 to 30th September 2015 at our centre. The patients were evaluated clinically and radiologically for functional outcomes. All patients were followed up for an average of 12 months. Outcome was assessed using NEER’s score.Results: 8 of my patients were male and 12 were female. All of them were closed injuries and fresh cases. The mean age was 51.8 years (21-68 yrs). 13 patients sustained RTA and 7 patients had accidental fall. 8 patients had right sided distal femur fracture and 12 had left sided injury. According to NEER’s score 50% had excellent results, 35% had good results and 15% had fair results. Gait and weight bearing after union was satisfactory. Range of motion of knee joint in majority of patients was within acceptable limits. Conclusions: Closed reduction and internal fixation of fracture lower end of femur by MIPO using LCP is one of the best modalities of treatment for good results

Acute toxicity study of seeds of Achyranthes aspera, bark of Berberis aristata and roots of Coleus forskohlii in Wistar rats

Background: Achyranthes aspera is a species of plant in the family Amaranthaceae. Berberis aristata is a shrub belonging to the family Berberidaceae and the genus Berberis. Plectranthus barbatus is a tropical perennial plant related to the typical coleus species. It produces forskolin, an extract useful for pharmaceutical preparations and research in cell biology. It is belonging to Lamiaceae. The present study has been undertaken to study the toxic effects of hydro alcoholic extracts of A. aspera, B. aristata, C. forskohlii in albino Wistar rats and to establish the hazardous safety category of hydro alcoholic extracts of these plants as per organization for economic cooperation and development (OECD-423) guidelines and GHS classification system respectively.Methods: In acute toxicity study, the hydro-alcoholic extracts of all the above three plants were given orally at the dose of 2000 mg/kg b. w. to three rats in each group respectively in step I. Then, all the animals were observed for initial 4 hours and followed by fourteen days for their clinical signs and mortality in step II.Results: In step I, all the animals were normal and there was no mortality after 48 hours. In step II with the same dose, all the animals showed no adverse effects and no mortality when followed up to 14 days observation period.Conclusions: The result indicates that the hydro alcoholic extracts of A. aspera, B. aristata, C. forskohlii plants can be utilized safely for therapeutic use in pharmaceutical formulations and it falls under category ‘5’ or ‘unclassified’ of GHS system

Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

Loss of insulin-secreting β-cells in diabetes may be either due to apoptosis or dedifferentiation of β-cell mass. The ubiquitin-proteasome system comprising E3 ligase and deubiquitinases (DUBs) controls several aspects of β-cell functions. In this study, screening for key DUBs identified USP1 to be specifically involved in dedifferentiation process. Inhibition of USP1 either by genetic intervention or small-molecule inhibitor ML323 restored epithelial phenotype of β-cells, but not with inhibition of other DUBs. In absence of dedifferentiation cues, overexpression of USP1 was sufficient to induce dedifferentiation in β-cells; mechanistic insight showed USP1 to mediate its effect via modulating the expression of inhibitor of differentiation (ID) 2. In an in vivo streptozotocin (STZ)-induced dedifferentiation mouse model system, administering ML323 alleviated hyperglycemic state. Overall, this study identifies USP1 to be involved in dedifferentiation of β-cells and its inhibition may have a therapeutic application of reducing β-cell loss during diabetes